[HTML][HTML] Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
N Igarashi, T Okada, S Hayashi, T Fujita… - Journal of Biological …, 2003 - ASBMB
Sphingosine kinase-1 (SPHK1) is a key enzyme catalyzing the formation of an important
bioactive lipid messenger, sphingosine 1-phosphate, and is implicated in the regulation of
cell proliferation and antiapoptotic processes. Biological features of another isozyme
SPHK2, however, remain unclear. The present studies were undertaken to characterize
SPHK2 by comparison with SPHK1. When SPHK2 was transiently expressed in various cell
lines, it was localized in the nuclei as well as in the cytosol, whereas SPHK1 was distributed …
bioactive lipid messenger, sphingosine 1-phosphate, and is implicated in the regulation of
cell proliferation and antiapoptotic processes. Biological features of another isozyme
SPHK2, however, remain unclear. The present studies were undertaken to characterize
SPHK2 by comparison with SPHK1. When SPHK2 was transiently expressed in various cell
lines, it was localized in the nuclei as well as in the cytosol, whereas SPHK1 was distributed …