[HTML][HTML] Sphingosine 1-phosphate modulates spinal nociceptive processing
O Coste, C Brenneis, B Linke, S Pierre… - Journal of biological …, 2008 - ASBMB
Sphingosine 1-Phosphate (S1P) modulates various cellular functions such as apoptosis, cell
differentiation, and migration. Although S1P is an abundant signaling molecule in the central
nervous system, very little is known about its influence on neuronal functions. We found that
S1P concentrations were selectively decreased in the cerebrospinal fluid of adult rats in an
acute and an inflammatory pain model. Pharmacological inhibition of sphingosine kinases
(SPHK) decreased basal pain thresholds and SphK2 knock-out mice, but not SphK1 knock …
differentiation, and migration. Although S1P is an abundant signaling molecule in the central
nervous system, very little is known about its influence on neuronal functions. We found that
S1P concentrations were selectively decreased in the cerebrospinal fluid of adult rats in an
acute and an inflammatory pain model. Pharmacological inhibition of sphingosine kinases
(SPHK) decreased basal pain thresholds and SphK2 knock-out mice, but not SphK1 knock …