Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following …
CO Ladd, RL Huot, KV Thrivikraman, CB Nemeroff… - Biological …, 2004 - Elsevier
BACKGROUND: Maternally separated rats exhibit exaggerated hypothalamic-pituitary-
adrenal responses to an acute stressor but normal diurnal trough functioning. We
hypothesized that maternally separated rats experience adequate proactive glucocorticoid
negative feedback but deficient “reactive” negative feedback, contributing to prolonged
hypothalamic-pituitary-adrenal stress responses. METHODS: We measured plasma
adrenocorticotropic hormone and corticosterone concentrations following an acute stressor …
adrenal responses to an acute stressor but normal diurnal trough functioning. We
hypothesized that maternally separated rats experience adequate proactive glucocorticoid
negative feedback but deficient “reactive” negative feedback, contributing to prolonged
hypothalamic-pituitary-adrenal stress responses. METHODS: We measured plasma
adrenocorticotropic hormone and corticosterone concentrations following an acute stressor …