Figure 1. Graphical display of ratings of general quality of life (Modular System for the assessment of Quality of Life subscale 1.710)(bars), mood (Beck Depression Inventory (BDI)), anxiety (Hamilton Anxiety Scale (HAMA)) and craving (VAS)(dashed and solid line) over a 2 and 1 year period of stimulation for patient 1 and 2, respectively.(Shortly before his 2 years follow-up examination, patient 1 reported a significant increase of alcohol and amphetamine consumption, accompanied by an increase of BDI and HAMA values, and an abatement of quality of life. However, an exchange of the battery was followed by a recovery of his psychiatric symptoms. We speculate that unchanged craving might be related to persisting synaptic plasticity2).(Funded by DFG (German Research Foundation) KFO 219, Else Kröner-Fresenius-Stiftung and BMBF (German Federal Ministry of Education and Research (01KN1106)).