[HTML][HTML] Mast cell tryptase controls paracellular permeability of the intestine: role of protease-activated receptor 2 and β-arrestins
C Jacob, PC Yang, D Darmoul, S Amadesi… - Journal of Biological …, 2005 - ASBMB
Tight junctions between intestinal epithelial cells prevent ingress of luminal macromolecules
and bacteria and protect against inflammation and infection. During stress and inflammation,
mast cells mediate increased mucosal permeability by unknown mechanisms. We
hypothesized that mast cell tryptase cleaves protease-activated receptor 2 (PAR 2) on
colonocytes to increase paracellular permeability. Colonocytes expressed PAR 2 mRNA
and responded to PAR 2 agonists with increased [Ca 2+] i. Supernatant from degranulated …
and bacteria and protect against inflammation and infection. During stress and inflammation,
mast cells mediate increased mucosal permeability by unknown mechanisms. We
hypothesized that mast cell tryptase cleaves protease-activated receptor 2 (PAR 2) on
colonocytes to increase paracellular permeability. Colonocytes expressed PAR 2 mRNA
and responded to PAR 2 agonists with increased [Ca 2+] i. Supernatant from degranulated …