[HTML][HTML] Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis
JS Carew, CM Espitia, JA Esquivel… - Journal of Biological …, 2011 - ASBMB
Cellular stress induced by nutrient deprivation, hypoxia, and exposure to many
chemotherapeutic agents activates an evolutionarily conserved cell survival pathway termed
autophagy. This pathway enables cancer cells to undergo self-digestion to generate ATP
and other essential biosynthetic molecules to temporarily avoid cell death. Therefore,
disruption of autophagy may sensitize cancer cells to cell death and augment chemotherapy-
induced apoptosis. Chloroquine and its analog hydroxychloroquine are the only clinically …
chemotherapeutic agents activates an evolutionarily conserved cell survival pathway termed
autophagy. This pathway enables cancer cells to undergo self-digestion to generate ATP
and other essential biosynthetic molecules to temporarily avoid cell death. Therefore,
disruption of autophagy may sensitize cancer cells to cell death and augment chemotherapy-
induced apoptosis. Chloroquine and its analog hydroxychloroquine are the only clinically …