[HTML][HTML] Therapeutic induction of autophagy to modulate neurodegenerative disease progression
WE Hochfeld, S Lee, DC Rubinsztein - Acta Pharmacologica Sinica, 2013 - nature.com
WE Hochfeld, S Lee, DC Rubinsztein
Acta Pharmacologica Sinica, 2013•nature.comThere is accumulating evidence that aggregating, misfolded proteins may have an impact on
autophagic function, suggesting that this could be a secondary pathological mechanism in
many diseases. In this review, we focus on the role of autophagy in four major
neurodegenerative diseases: Alzheimer disease (AD), Huntington's disease (HD),
Parkinson's disease (PD) and amyotropic lateral sclerosis.
autophagic function, suggesting that this could be a secondary pathological mechanism in
many diseases. In this review, we focus on the role of autophagy in four major
neurodegenerative diseases: Alzheimer disease (AD), Huntington's disease (HD),
Parkinson's disease (PD) and amyotropic lateral sclerosis.
Abstract
There is accumulating evidence that aggregating, misfolded proteins may have an impact on autophagic function, suggesting that this could be a secondary pathological mechanism in many diseases. In this review, we focus on the role of autophagy in four major neurodegenerative diseases: Alzheimer disease (AD), Huntington's disease (HD), Parkinson's disease (PD) and amyotropic lateral sclerosis.
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