[HTML][HTML] Effect of glucagon-like peptide-1 receptor antagonism on appetite and food intake in healthy men
RE Steinert, J Schirra, AC Meyer-Gerspach… - The American journal of …, 2014 - Elsevier
Background: Exogenous glucagon-like peptide-1 (GLP-1) inhibits eating in healthy,
overweight, and diabetic subjects. Objective: The GLP-1 receptor antagonist exendin (9–39)
NH2 (ex9–39) was used to further explore the role of GLP-1 as an endogenous satiation
signal. Design: Two double-blind, 4-way crossover studies were performed, each of which
included 10 healthy men. In study A, subjects received an intravenous infusion of ex9–39 or
saline plus an oral glucose preload and an intraduodenal infusion of saline or glucose for 60 …
overweight, and diabetic subjects. Objective: The GLP-1 receptor antagonist exendin (9–39)
NH2 (ex9–39) was used to further explore the role of GLP-1 as an endogenous satiation
signal. Design: Two double-blind, 4-way crossover studies were performed, each of which
included 10 healthy men. In study A, subjects received an intravenous infusion of ex9–39 or
saline plus an oral glucose preload and an intraduodenal infusion of saline or glucose for 60 …