Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression
IR Moldovan, RA Rudick, AC Cotleur, SE Born… - Journal of …, 2003 - Elsevier
The relationship between autoreactivity to myelin antigens and disease progression in
multiple sclerosis (MS) is not fully understood. We addressed this relationship by cross-
sectionally comparing an objective measure of MS disability with immune cytokine
responses to myelin proteins. The ELISPOT assay was used to determine the ex vivo
interferon gamma (IFNγ) and interleukin-10 (IL-10) production by peripheral blood
mononuclear cells (PBMCs) in response to peptides spanning the entire proteolipid protein …
multiple sclerosis (MS) is not fully understood. We addressed this relationship by cross-
sectionally comparing an objective measure of MS disability with immune cytokine
responses to myelin proteins. The ELISPOT assay was used to determine the ex vivo
interferon gamma (IFNγ) and interleukin-10 (IL-10) production by peripheral blood
mononuclear cells (PBMCs) in response to peptides spanning the entire proteolipid protein …
