Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria
C Voisine, B Mastelic, AM Sponaas… - International journal for …, 2010 - Elsevier
Dendritic cells play an important role in the development of immune responses in malaria,
but the contribution of plasmacytoid dendritic cells (pDC) to CD4 T cell activation and
immunopathology is unknown. We have investigated pDC in a Plasmodium chabaudi
infection in mice. During infection, pDC increased in number and transiently up-regulated
expression of Major Histocompatibility Complex class II and co-stimulatory molecules.
However, in contrast to classical CD11chigh DC, pDC could not phagocytose parasites or …
but the contribution of plasmacytoid dendritic cells (pDC) to CD4 T cell activation and
immunopathology is unknown. We have investigated pDC in a Plasmodium chabaudi
infection in mice. During infection, pDC increased in number and transiently up-regulated
expression of Major Histocompatibility Complex class II and co-stimulatory molecules.
However, in contrast to classical CD11chigh DC, pDC could not phagocytose parasites or …