Exenatide and feeding: possible peripheral neuronal pathways
JV Hunt, MC Washington, AI Sayegh - Peptides, 2012 - Elsevier
Intraperitoneal (ip) administration of the synthetic agonist of the glucagon like peptide-1
(GLP-1) receptor exenatide reduces food intake. Here, we evaluated possible peripheral
pathways for this reduction. Exenatide (0.5 μg/kg, ip) was given to three, overnight food-
deprived, groups of rats: total subdiaphragmatic vagotomy (VGX, severs the vagus nerve),
celiaco-mesenteric ganglionectomy (CMGX, severs the splanchnic nerve) and combined
VGX/CMGX. Following the injection, meal sizes (MSs) and intermeal intervals (IMIs) were …
(GLP-1) receptor exenatide reduces food intake. Here, we evaluated possible peripheral
pathways for this reduction. Exenatide (0.5 μg/kg, ip) was given to three, overnight food-
deprived, groups of rats: total subdiaphragmatic vagotomy (VGX, severs the vagus nerve),
celiaco-mesenteric ganglionectomy (CMGX, severs the splanchnic nerve) and combined
VGX/CMGX. Following the injection, meal sizes (MSs) and intermeal intervals (IMIs) were …