Scavenger receptor class B type I: a multifunctional receptor
G Valacchi, C Sticozzi, Y Lim… - Annals of the New York …, 2011 - Wiley Online Library
Annals of the New York Academy of Sciences, 2011•Wiley Online Library
The scavenger receptor class B type I (SR‐B1) plays an important role in meditating the
uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic
tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor
in many tissues, though the mechanism by which SR‐B1 does this is unclear. Other than its
role as an HDL receptor, SR‐B1 is also involved in pathogen recognition; its expression can
be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in …
uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic
tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor
in many tissues, though the mechanism by which SR‐B1 does this is unclear. Other than its
role as an HDL receptor, SR‐B1 is also involved in pathogen recognition; its expression can
be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in …
The scavenger receptor class B type I (SR‐B1) plays an important role in meditating the uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR‐B1 does this is unclear. Other than its role as an HDL receptor, SR‐B1 is also involved in pathogen recognition; its expression can be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in the uptake of lipid soluble vitamins, such as vitamin E and carotenoids. In this short review, we have summarized the biological aspects to which SR‐B1 has been thus far associated.
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