Interferon-γ-mediated pathways are induced in human CD34+ haematopoietic stem cells
K Kurz, Y Gluhcheva, E Zvetkova, G Konwalinka… - Immunobiology, 2010 - Elsevier
Pro-inflammatory cytokines like interferon-γ (IFN-γ) are considered to be important in the
development of anaemia of chronic disease (ACD). Both, inhibitory and stimulatory activities
of IFN-γ on erythropoiesis have been observed in vitro earlier. IFN-γ induces several
biochemical pathways in human monocytes, among them neopterin formation by GTP-
cyclohydrolase I (GTP-CH I) and tryptophan degradation by the enzyme indoleamine 2, 3-
dioxygenase (IDO). IDO-mediated tryptophan deprivation efficiently inhibits the growth of …
development of anaemia of chronic disease (ACD). Both, inhibitory and stimulatory activities
of IFN-γ on erythropoiesis have been observed in vitro earlier. IFN-γ induces several
biochemical pathways in human monocytes, among them neopterin formation by GTP-
cyclohydrolase I (GTP-CH I) and tryptophan degradation by the enzyme indoleamine 2, 3-
dioxygenase (IDO). IDO-mediated tryptophan deprivation efficiently inhibits the growth of …
