Regenerative tissues such as the skin epidermis, the intestinal mucosa or the hematopoietic
system are organized in a hierarchical manner with stem cells building the top of this
hierarchy. Somatic stem cells harbor the highest self-renewal activity and generate a series
of multipotent progenitors which differentiate into lineage committed progenitors and
subsequently mature cells. In this report, we applied an in-depth quantitative proteomic
approach to analyze and compare the full proteomes of ex vivo isolated and FACS-sorted …