What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?
XJ Xu, WJ Pories, LG Dohm… - Current opinion in …, 2013 - journals.lww.com
XJ Xu, WJ Pories, LG Dohm, NB Ruderman
Current opinion in lipidology, 2013•journals.lww.comAvailable data suggest that increases in oxidative stress, decreases in AMPK activity and
SIRT1 gene expression, depot-specific changes in inflammatory, mitochondrial and other
genes distinguish adipose tissue of insulin resistant from insulin-sensitive individuals with
severe obesity.
SIRT1 gene expression, depot-specific changes in inflammatory, mitochondrial and other
genes distinguish adipose tissue of insulin resistant from insulin-sensitive individuals with
severe obesity.
Summary
Available data suggest that increases in oxidative stress, decreases in AMPK activity and SIRT1 gene expression, depot-specific changes in inflammatory, mitochondrial and other genes distinguish adipose tissue of insulin resistant from insulin-sensitive individuals with severe obesity.
Lippincott Williams & Wilkins