Harmine tremor after brain monoamine oxidase inhibition in the mouse

GH Coates, B Cox - European journal of pharmacology, 1972 - Elsevier
GH Coates, B Cox
European journal of pharmacology, 1972Elsevier
The TD 50 for harmine in mebanazine-pretreated mice was not significantly different from
that in untreated mice. Mebanazine (20 mg/kg sc) gave a 99% inhibition of brain monoamine
oxidase without tremor. Thus harmine tremor is not related to its effect on brain monoamine
oxidase.
Abstract
The TD50 for harmine in mebanazine-pretreated mice was not significantly different from that in untreated mice. Mebanazine (20 mg/kg s.c.) gave a 99% inhibition of brain monoamine oxidase without tremor. Thus harmine tremor is not related to its effect on brain monoamine oxidase.
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