[HTML][HTML] The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2
C Hong, S Duit, P Jalonen, R Out, L Scheer… - Journal of Biological …, 2010 - ASBMB
We have previously identified the E3 ubiquitin ligase-inducible degrader of the low density
lipoprotein receptor (LDLR)(Idol) as a post-translational modulator of LDLR levels. Idol is a
direct target for regulation by liver X receptors (LXRs), and its expression is responsive to
cellular sterol status independent of the sterol-response element-binding proteins. Here we
demonstrate that Idol also targets two closely related LDLR family members, VLDLR and
ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid …
lipoprotein receptor (LDLR)(Idol) as a post-translational modulator of LDLR levels. Idol is a
direct target for regulation by liver X receptors (LXRs), and its expression is responsive to
cellular sterol status independent of the sterol-response element-binding proteins. Here we
demonstrate that Idol also targets two closely related LDLR family members, VLDLR and
ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid …