The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma
X Cheng, Z Zhao, E Ventura, B Gran… - Journal of …, 2007 - Elsevier
Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
(MS), is mediated by autoantigen-specific T-helper1 (Th1) cells. IL-12, an inducer of Th1 cell
development, exerts immunomodulatory effects in EAE. Programmed death-1 (PD-1) and
PD-1 ligand (PD-L), new members of the B7 superfamily of costimulatory molecules, play a
critical role in regulating EAE. Whether the interaction of IL-12 and the PD-1/PD-L pathway
regulates EAE is unclear. We have previously shown that IL-12 suppresses EAE induced by …
(MS), is mediated by autoantigen-specific T-helper1 (Th1) cells. IL-12, an inducer of Th1 cell
development, exerts immunomodulatory effects in EAE. Programmed death-1 (PD-1) and
PD-1 ligand (PD-L), new members of the B7 superfamily of costimulatory molecules, play a
critical role in regulating EAE. Whether the interaction of IL-12 and the PD-1/PD-L pathway
regulates EAE is unclear. We have previously shown that IL-12 suppresses EAE induced by …
