Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial
GU Meduri, AS Headley, E Golden, SJ Carson… - Jama, 1998 - jamanetwork.com
Context.—No pharmacological therapeutic protocol has been found effective in modifying
the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains
greater than 50%. Objective.—To determine the effects of prolonged methylprednisolone
therapy on lung function and mortality in patients with unresolving ARDS. Design.—
Randomized, double-blind, placebo-controlled trial. Setting.—Medical intensive care units of
4 medical centers. Participants.—Twenty-four patients with severe ARDS who had failed to …
the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains
greater than 50%. Objective.—To determine the effects of prolonged methylprednisolone
therapy on lung function and mortality in patients with unresolving ARDS. Design.—
Randomized, double-blind, placebo-controlled trial. Setting.—Medical intensive care units of
4 medical centers. Participants.—Twenty-four patients with severe ARDS who had failed to …
