Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke
S Rajendrasozhan, JW Hwang, H Yao… - Pulmonary …, 2010 - Elsevier
RATIONALE: IκB kinase (IKK) activates NF-κB which plays a pivotal role in pro-inflammatory
response in the lung. NF-κB has been shown to be activated in alveolar macrophages and
peripheral lungs of smokers and patients with chronic obstructive pulmonary disease. We
investigated the anti-inflammatory effect of a highly selective and novel IKKβ/IKK2 inhibitor,
PHA-408 [8-(5-chloro-2-(4-methylpiperazin-1-yl) isonicotinamido)-1-(4-fluorophenyl)-4, 5-
dihydro-1H-benzo [γ] indazole-3-carboxamide], in lungs of rat in vivo. METHODS: Adult …
response in the lung. NF-κB has been shown to be activated in alveolar macrophages and
peripheral lungs of smokers and patients with chronic obstructive pulmonary disease. We
investigated the anti-inflammatory effect of a highly selective and novel IKKβ/IKK2 inhibitor,
PHA-408 [8-(5-chloro-2-(4-methylpiperazin-1-yl) isonicotinamido)-1-(4-fluorophenyl)-4, 5-
dihydro-1H-benzo [γ] indazole-3-carboxamide], in lungs of rat in vivo. METHODS: Adult …
