Guanylyl cyclase-linked natriuretic peptide receptors: structure and regulation
LR Potter, T Hunter - Journal of Biological Chemistry, 2001 - ASBMB
In 1956, two seemingly disparate but profoundly prophetic papers were published. Kisch (1)
observed that atrial, but not ventricular, cardiac cells contain a highly developed Golgi
network, reminiscent of a secretory system, and Henry and colleagues (2) discovered that
elevated left atrial pressure stimulates urine output. Twenty-five years later the connection
between these studies and the heart and the kidney was made when de Bold and
colleagues (3) determined that rat atrial extracts contain a potent diuretic and natriuretic …
observed that atrial, but not ventricular, cardiac cells contain a highly developed Golgi
network, reminiscent of a secretory system, and Henry and colleagues (2) discovered that
elevated left atrial pressure stimulates urine output. Twenty-five years later the connection
between these studies and the heart and the kidney was made when de Bold and
colleagues (3) determined that rat atrial extracts contain a potent diuretic and natriuretic …
