[HTML][HTML] Heparan sulfate 6-O-sulfotransferase is essential for muscle development in zebrafish
RJ Bink, H Habuchi, Z Lele, E Dolk, J Joore… - Journal of Biological …, 2003 - ASBMB
Heparan sulfate proteoglycans function in development and disease. They consist of a core
protein with attached heparan sulfate chains that are altered by a series of carbohydrate-
modifying enzymes and sulfotransferases. Here, we report on the identification and
characterization of a gene encoding zebrafish heparan sulfate 6-O-sulfotransferase (hs6st)
that shows high homology to other heparan sulfate 6-O-sulfotransferases. When expressed
as a fusion protein in cultured cells, the protein shows specific 6-O-sulfotransferase activity …
protein with attached heparan sulfate chains that are altered by a series of carbohydrate-
modifying enzymes and sulfotransferases. Here, we report on the identification and
characterization of a gene encoding zebrafish heparan sulfate 6-O-sulfotransferase (hs6st)
that shows high homology to other heparan sulfate 6-O-sulfotransferases. When expressed
as a fusion protein in cultured cells, the protein shows specific 6-O-sulfotransferase activity …
