[HTML][HTML] Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
LB Frankel, NR Christoffersen, A Jacobsen… - Journal of Biological …, 2008 - ASBMB
MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21
microRNA is overexpressed in a wide variety of cancers and has been causally linked to
cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer
cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted
of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-
21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor …
microRNA is overexpressed in a wide variety of cancers and has been causally linked to
cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer
cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted
of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-
21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor …
