[HTML][HTML] Innate immune response triggers lupus-like autoimmune disease
JC Paulson - Cell, 2007 - cell.com
Cell, 2007•cell.com
Autoimmune disease is typically defined as an aberrant response of lymphocytes to self
antigens that ultimately leads to tissue damage. Reporting in Immunity, Green et al.(2007)
now show that mice lacking α-mannosidase II develop an autoimmune disease similar to
lupus. Remarkably, this illness is precipitated by an innate immune response to altered self
glycans that mimic molecular patterns found on pathogens.
antigens that ultimately leads to tissue damage. Reporting in Immunity, Green et al.(2007)
now show that mice lacking α-mannosidase II develop an autoimmune disease similar to
lupus. Remarkably, this illness is precipitated by an innate immune response to altered self
glycans that mimic molecular patterns found on pathogens.
Autoimmune disease is typically defined as an aberrant response of lymphocytes to self antigens that ultimately leads to tissue damage. Reporting in Immunity, Green et al. (2007) now show that mice lacking α-mannosidase II develop an autoimmune disease similar to lupus. Remarkably, this illness is precipitated by an innate immune response to altered self glycans that mimic molecular patterns found on pathogens.
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