[HTML][HTML] The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor α1 (IL13Rα1)
RT Martinez-Nunez, F Louafi… - Journal of Biological …, 2011 - ASBMB
Macrophages play a central role in the balance and efficiency of the immune response and
are at the interface between innate and adaptive immunity. Their phenotype is a delicate
equilibrium between the M1 (classical, pro-Th 1) and M2 (alternative, pro-Th 2) profiles. This
balance is regulated by cytokines such as interleukin 13 (IL-13), a typical pro-M2-Th 2
cytokine that has been related to allergic disease and asthma. IL-13 binds to IL-13 receptor
α1 (IL13Rα1), a component of the Type II IL-4 receptor, and exerts its effects by activating the …
are at the interface between innate and adaptive immunity. Their phenotype is a delicate
equilibrium between the M1 (classical, pro-Th 1) and M2 (alternative, pro-Th 2) profiles. This
balance is regulated by cytokines such as interleukin 13 (IL-13), a typical pro-M2-Th 2
cytokine that has been related to allergic disease and asthma. IL-13 binds to IL-13 receptor
α1 (IL13Rα1), a component of the Type II IL-4 receptor, and exerts its effects by activating the …