Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease
E Rodríguez, H Baurecht, E Herberich… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: The discovery of filaggrin (FLG) null mutations as a major risk factor for
eczema represents a milestone toward the understanding of an important mechanism in this
complex disease. However, published studies demonstrate differences concerning design
and effect size, and conflicting results for asthma have been reported. OBJECTIVES: We
sought to provide a more accurate estimate of FLG effect sizes and to better refine FLG risk
profiles within the broad and inclusive eczema diagnosis. We also sought to provide a more …
eczema represents a milestone toward the understanding of an important mechanism in this
complex disease. However, published studies demonstrate differences concerning design
and effect size, and conflicting results for asthma have been reported. OBJECTIVES: We
sought to provide a more accurate estimate of FLG effect sizes and to better refine FLG risk
profiles within the broad and inclusive eczema diagnosis. We also sought to provide a more …
