Direct Fetal Administration of Immunogíobulins: Another Disappointing Therapy in Alloimmune Thrombocytopenia
E Weiner, N Zosmer, R Bajoria, W Sepulveda… - Fetal diagnosis and …, 1994 - karger.com
Fetal diagnosis and therapy, 1994•karger.com
Current management strategies to prevent fetal intracranial haemorrhage in perinatal
alloimmune thrombocytopenia (PAIT) include serial platelet transfusion and/or maternal high-
dose intravenous immunoglobulin (IVIG) administration. The former involves multiple
invasive procedures, while the latter is both expensive and of questionable efficacy. We
report the use of direct fetal IVIG in 2 fetuses with PAIT, undergoing serial intrauterine
platelet transfusions. Fetal IVIG had no effect on fetal platelet count. We conclude that direct …
alloimmune thrombocytopenia (PAIT) include serial platelet transfusion and/or maternal high-
dose intravenous immunoglobulin (IVIG) administration. The former involves multiple
invasive procedures, while the latter is both expensive and of questionable efficacy. We
report the use of direct fetal IVIG in 2 fetuses with PAIT, undergoing serial intrauterine
platelet transfusions. Fetal IVIG had no effect on fetal platelet count. We conclude that direct …
Abstract
Current management strategies to prevent fetal intracranial haemorrhage in perinatal alloimmune thrombocytopenia (PAIT) include serial platelet transfusion and/or maternal high-dose intravenous immunoglobulin (IVIG) administration. The former involves multiple invasive procedures, while the latter is both expensive and of questionable efficacy. We report the use of direct fetal IVIG in 2 fetuses with PAIT, undergoing serial intrauterine platelet transfusions. Fetal IVIG had no effect on fetal platelet count. We conclude that direct fetal IVIG administration does not appear to have a role in the management of PAIT, and that current management strategies remain far from ideal.
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