[HTML][HTML] Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus
JL Hood, WH Brooks, TL Roszman - Journal of Biological Chemistry, 2004 - ASBMB
Calpain, a calcium-activated cysteine protease, is involved in modulating a variety of cell
activities such as shape change, mobility, and apoptosis. The two ubiquitous isoforms of this
protease, calpain I and II, are considered to be cytosolic proteins that can translocate to
various sites in the cell. The activity of calpain is modulated by two regulatory proteins,
calpastatin, the specific endogenous inhibitor of calpain, and the 28-kDa regulatory subunit.
Using velocity gradient centrifugation, the results of this study confirm and greatly expand …
activities such as shape change, mobility, and apoptosis. The two ubiquitous isoforms of this
protease, calpain I and II, are considered to be cytosolic proteins that can translocate to
various sites in the cell. The activity of calpain is modulated by two regulatory proteins,
calpastatin, the specific endogenous inhibitor of calpain, and the 28-kDa regulatory subunit.
Using velocity gradient centrifugation, the results of this study confirm and greatly expand …
