Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli
The μ-and m-calpain proteases have been implicated in both pro-or anti-apoptotic functions.
Here we compared cell death responses and apoptotic or survival signaling pathways in
primary mouse embryonic fibroblasts (MEFs) derived from wild type or capn4 knock-out mice
which lack both μ-and m-calpain activities. Capn4–/–MEFs displayed resistance to
puromycin, camptothecin, etoposide, hydrogen peroxide, ultraviolet light, and serum
starvation, which was consistent with pro-apoptotic roles for calpain. In contrast, capn4 …
Here we compared cell death responses and apoptotic or survival signaling pathways in
primary mouse embryonic fibroblasts (MEFs) derived from wild type or capn4 knock-out mice
which lack both μ-and m-calpain activities. Capn4–/–MEFs displayed resistance to
puromycin, camptothecin, etoposide, hydrogen peroxide, ultraviolet light, and serum
starvation, which was consistent with pro-apoptotic roles for calpain. In contrast, capn4 …
