Characterization of distant enhancers and promoters in the albumin-α-fetoprotein locus during active and silenced expression
Y Kajiyama, J Tian, J Locker - Journal of biological chemistry, 2006 - ASBMB
The albumin and α-fetoprotein genes are adjacent and express closely related serum
proteins. Both genes are strongly expressed in fetal liver, primarily through activation by
distant enhancers, but the AFP gene selectively undergoes developmental silencing. We
used chromatin immunoprecipitation to study enhancers and promoters during active and
silenced gene expression. In adult phenotype cells, the silenced AFP gene was actively
repressed at the promoter and two proximal enhancers, characterized by the absence of …
proteins. Both genes are strongly expressed in fetal liver, primarily through activation by
distant enhancers, but the AFP gene selectively undergoes developmental silencing. We
used chromatin immunoprecipitation to study enhancers and promoters during active and
silenced gene expression. In adult phenotype cells, the silenced AFP gene was actively
repressed at the promoter and two proximal enhancers, characterized by the absence of …
