[HTML][HTML] Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
Neuronal Cdc2-like kinase (Nclk) plays an important role in a variety of cellular processes,
including neuronal cell differentiation, apoptosis, neuron migration, and formation of
neuromuscular junction. The active kinase consists of a catalytic subunit, Cdk5, and an
essential regulatory subunit, neuronal Cdk5 activator (p35 nck5a or p25 nck5a), which is
expressed primarily in neurons of central nervous tissue. In our previous study using the
yeast two-hybrid screening method, three novel p35 nck5a-associated proteins were …
including neuronal cell differentiation, apoptosis, neuron migration, and formation of
neuromuscular junction. The active kinase consists of a catalytic subunit, Cdk5, and an
essential regulatory subunit, neuronal Cdk5 activator (p35 nck5a or p25 nck5a), which is
expressed primarily in neurons of central nervous tissue. In our previous study using the
yeast two-hybrid screening method, three novel p35 nck5a-associated proteins were …