Endothelial monocyte activating polypeptide II induces endothelial cell apoptosis and may inhibit tumor angiogenesis
AC Berger, HR Alexander, G Tang, PS Wu… - Microvascular …, 2000 - Elsevier
Endothelial monocyte activating polypeptide II (EMAP-II) is a tumor-derived cytokine with
potent effects on endothelial cells in vitro and in vivo including upregulation of tissue factor
and the sensitization of human melanoma to systemic TNF treatment via its effects on the
tumor vasculature. We investigated the effects of EMAP-II on tumor growth, angiogenesis,
vasculogenesis, and apoptosis. EMAP-II inhibited endothelial cell proliferation,
vasculogenesis, and neovessel formation. In vivo growth of human melanoma lines …
potent effects on endothelial cells in vitro and in vivo including upregulation of tissue factor
and the sensitization of human melanoma to systemic TNF treatment via its effects on the
tumor vasculature. We investigated the effects of EMAP-II on tumor growth, angiogenesis,
vasculogenesis, and apoptosis. EMAP-II inhibited endothelial cell proliferation,
vasculogenesis, and neovessel formation. In vivo growth of human melanoma lines …
