Generation of murine hepatic lineage cells from induced pluripotent stem cells
H Gai, DM Nguyen, YJ Moon, JR Aguila, LM Fink… - Differentiation, 2010 - Elsevier
Induced pluripotent stem (iPS) cells can be generated from somatic cells of individuals by
retrodifferentiation using defined transcription factors. Similar to embryonic stem (ES) cells,
iPS cells can be differentiated into a variety of specific cell types. However, to date, no
detailed hepatic differentiation of mouse iPS cells has been reported. In this study, we
successfully developed a stepwise protocol to induce hepatic differentiation of iPS cells
reprogrammed from mouse tail tip fibroblasts. At day 25 of differentiation, the iPS cell …
retrodifferentiation using defined transcription factors. Similar to embryonic stem (ES) cells,
iPS cells can be differentiated into a variety of specific cell types. However, to date, no
detailed hepatic differentiation of mouse iPS cells has been reported. In this study, we
successfully developed a stepwise protocol to induce hepatic differentiation of iPS cells
reprogrammed from mouse tail tip fibroblasts. At day 25 of differentiation, the iPS cell …
