Regulation of neutrophil homeostasis
MJ Christopher, DC Link - Current opinion in hematology, 2007 - journals.lww.com
MJ Christopher, DC Link
Current opinion in hematology, 2007•journals.lww.comGranulocyte colony-stimulating factor plays a central role in the dynamic regulation of
neutrophil production and release from the bone marrow in response to environmental
stresses. Recent studies have begun to elucidate both the pathways linking neutrophil
clearance to granulocyte colony-stimulating factor expression and the mechanisms by which
the factor induces neutrophil release from the bone marrow. These studies may lead to
novel strategies to modulate neutrophil responses in host defense and inflammation.
neutrophil production and release from the bone marrow in response to environmental
stresses. Recent studies have begun to elucidate both the pathways linking neutrophil
clearance to granulocyte colony-stimulating factor expression and the mechanisms by which
the factor induces neutrophil release from the bone marrow. These studies may lead to
novel strategies to modulate neutrophil responses in host defense and inflammation.
Summary
Granulocyte colony-stimulating factor plays a central role in the dynamic regulation of neutrophil production and release from the bone marrow in response to environmental stresses. Recent studies have begun to elucidate both the pathways linking neutrophil clearance to granulocyte colony-stimulating factor expression and the mechanisms by which the factor induces neutrophil release from the bone marrow. These studies may lead to novel strategies to modulate neutrophil responses in host defense and inflammation.
Lippincott Williams & Wilkins