[HTML][HTML] Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42
T Reid, A Bathoorn, MR Ahmadian… - Journal of Biological …, 1999 - ASBMB
Guanine nucleotide exchange factors of the Dbl family regulate the actin cytoskeleton
through activation of Rho-like GTPases. At present the Dbl family consists of more than thirty
members; many have not been phenotypically or biochemically characterized. Guanine
nucleotide exchange factors universally feature a Dbl homology domain followed by a
pleckstrin homology domain. Employing data base screening we identified a recently cloned
cDNA, KIAA0424, showing substantial sequence homology with Rac activators such as …
through activation of Rho-like GTPases. At present the Dbl family consists of more than thirty
members; many have not been phenotypically or biochemically characterized. Guanine
nucleotide exchange factors universally feature a Dbl homology domain followed by a
pleckstrin homology domain. Employing data base screening we identified a recently cloned
cDNA, KIAA0424, showing substantial sequence homology with Rac activators such as …
