[HTML][HTML] Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the …
S-Nitrosation of mitochondrial proteins has been proposed to contribute to the
pathophysiological interactions of nitric oxide (NO) and its derivatives with mitochondria but
has not been shown directly. Furthermore, little is known about the mechanism of formation
or the fate of these putative S-nitrosothiols. Here we have determined whether mitochondrial
membrane protein thiols can be S-nitrosated on exposure to free NO from 3, 3-bis
(aminoethyl)-1-hydroxy-2-oxo-1-triazene (DETA-NONOate) by interaction with S …
pathophysiological interactions of nitric oxide (NO) and its derivatives with mitochondria but
has not been shown directly. Furthermore, little is known about the mechanism of formation
or the fate of these putative S-nitrosothiols. Here we have determined whether mitochondrial
membrane protein thiols can be S-nitrosated on exposure to free NO from 3, 3-bis
(aminoethyl)-1-hydroxy-2-oxo-1-triazene (DETA-NONOate) by interaction with S …