Peroxisome proliferator-activated receptor-γ co-activator 1α (PGC1α) is a promiscuous co-
activator that plays a key role in regulating mitochondrial biogenesis and fuel homeostasis.
Emergent evidence links decreased skeletal muscle PGC1α activity and coincident
impairments in mitochondrial performance to the development of insulin resistance in
humans. Here we used rodent models to demonstrate that muscle mitochondrial efficiency is
compromised by diet-induced obesity and is subsequently rescued by exercise training …