Electrophysiological concomitants of spreading depression in caudate and thalamic nuclei of the cat
MC Trachtenberg, CD Hull, NA Buchwald - Brain Research, 1970 - Elsevier
MC Trachtenberg, CD Hull, NA Buchwald
Brain Research, 1970•ElsevierSpreading depression (SD) was induced by injection of KCl into striatal and thalamic sites.
Unit activity, EEG and direct coupled (DC) recordings were made simultaneously from a
number of different brain sites before and after KCl injection. Recording sites included the
nucleus into which the injection was made, contiguous nuclei (ie not separated by white
matter), known projection areas of the injected nucleus and areas which were anatomically
unrelated to the site of injection. The large slow potential changes characteristic of SD were …
Unit activity, EEG and direct coupled (DC) recordings were made simultaneously from a
number of different brain sites before and after KCl injection. Recording sites included the
nucleus into which the injection was made, contiguous nuclei (ie not separated by white
matter), known projection areas of the injected nucleus and areas which were anatomically
unrelated to the site of injection. The large slow potential changes characteristic of SD were …
Summary
Spreading depression (SD) was induced by injection of KCl into striatal and thalamic sites. Unit activity, EEG and direct coupled (DC) recordings were made simultaneously from a number of different brain sites before and after KCl injection. Recording sites included the nucleus into which the injection was made, contiguous nuclei (i.e. not separated by white matter), known projection areas of the injected nucleus and areas which were anatomically unrelated to the site of injection.
The large slow potential changes characteristic of SD were generally confined to the injected nucleus and to contiguous nuclei. Unit activity in these areas infrequently ceased, but firing rate and pattern were often dramatically changed. Smaller DC changes were recorded in projection areas. Changes in unit firing patterns were also induced in these areas. The EEG changes little at any subcortical recording site.
The experimental results suggest (1) that the method may have some utility as a neuronographic tool and (2) that subcortically-induced SD might be considered as a ‘disorganization’ rather than as a functional ablation.
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