[HTML][HTML] The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
K Balabanian, B Lagane, S Infantino, KYC Chow… - Journal of Biological …, 2005 - ASBMB
Combined phylogenetic and chromosomal location studies suggest that the orphan receptor
RDC1 is related to CXC chemokine receptors. RDC1 provides a co-receptor function for a
restricted number of human immunodeficiency virus (HIV) isolates, in particular for the
CXCR4-using HIV-2 ROD strain. Here we show that CXCL12, the only known natural ligand
for CXCR4, binds to and signals through RDC1. We demonstrate that RDC1 is expressed in
T lymphocytes and that CXCL12-promoted chemotaxis is inhibited by an anti-RDC1 …
RDC1 is related to CXC chemokine receptors. RDC1 provides a co-receptor function for a
restricted number of human immunodeficiency virus (HIV) isolates, in particular for the
CXCR4-using HIV-2 ROD strain. Here we show that CXCL12, the only known natural ligand
for CXCR4, binds to and signals through RDC1. We demonstrate that RDC1 is expressed in
T lymphocytes and that CXCL12-promoted chemotaxis is inhibited by an anti-RDC1 …
