Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis
M Hasegawa, M Fujimoto, K Takehara… - Journal of dermatological …, 2005 - Elsevier
Systemic sclerosis (SSc) is characterized by autoimmunity and tissue fibrosis. There is a
close association between specific autoantibodies and clinical features in patients with SSc.
A number of studies have demonstrated that various cytokines, such as transforming growth
factor-β, modulate the synthesis of extracellular matrix by fibroblasts. However, it is not clear
as to how autoimmunity and tissue fibrosis interact with each other. Recent studies have
revealed that B cells play a critical role in various systemic autoimmune disorders. CD19 is a …
close association between specific autoantibodies and clinical features in patients with SSc.
A number of studies have demonstrated that various cytokines, such as transforming growth
factor-β, modulate the synthesis of extracellular matrix by fibroblasts. However, it is not clear
as to how autoimmunity and tissue fibrosis interact with each other. Recent studies have
revealed that B cells play a critical role in various systemic autoimmune disorders. CD19 is a …
