Signaling and host cell invasion by Trypanosoma cruzi
BA Burleigh, NW Andrews - Current opinion in Microbiology, 1998 - Elsevier
Current opinion in Microbiology, 1998•Elsevier
Signal transduction events triggered in mammalian host cells by the obligate intracellular
parasite Trypanosoma cruzi are required for invasion. Infective T. cruzi trypomastigotes elicit
Ca2+ signaling in mammalian host cells and activate transforming growth factor-β receptor
signaling pathways. The elevation of Ca2+ in T. cruzi, induced by host-cell contact, is also
required for invasion, extending the concept of host—pathogen 'cross-talk'to invasive
protozoan pathogens.
parasite Trypanosoma cruzi are required for invasion. Infective T. cruzi trypomastigotes elicit
Ca2+ signaling in mammalian host cells and activate transforming growth factor-β receptor
signaling pathways. The elevation of Ca2+ in T. cruzi, induced by host-cell contact, is also
required for invasion, extending the concept of host—pathogen 'cross-talk'to invasive
protozoan pathogens.
Signal transduction events triggered in mammalian host cells by the obligate intracellular parasite Trypanosoma cruzi are required for invasion. Infective T. cruzi trypomastigotes elicit Ca2+ signaling in mammalian host cells and activate transforming growth factor-β receptor signaling pathways. The elevation of Ca2+ in T. cruzi, induced by host-cell contact, is also required for invasion, extending the concept of host—pathogen ‘cross-talk’ to invasive protozoan pathogens.
Elsevier
