Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells …
H Inoue, C Yokoyama, S Hara, Y Tone… - Journal of Biological …, 1995 - ASBMB
There exist two distinct isozymes of prostaglandin-endoperoxide synthase (PES). PES-2
mRNA is synergistically induced by lipopolysaccharide (LPS) and 12-O-
tetradecanoylphorbol-13-acetate (TPA) in bovine arterial endothelial cells. On the other
hand, PES-1 mRNA is constitutively expressed under these conditions. Therefore, the
promoter activities of the human genes for PES-1 and− 2 in bovine arterial endothelial cells
were examined. The 5′-flanking region of the human PES-2 gene (nucleotides− 327 to+ …
mRNA is synergistically induced by lipopolysaccharide (LPS) and 12-O-
tetradecanoylphorbol-13-acetate (TPA) in bovine arterial endothelial cells. On the other
hand, PES-1 mRNA is constitutively expressed under these conditions. Therefore, the
promoter activities of the human genes for PES-1 and− 2 in bovine arterial endothelial cells
were examined. The 5′-flanking region of the human PES-2 gene (nucleotides− 327 to+ …
