[HTML][HTML] A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high …
Scavenger receptor class B, type I (SR-BI)/ApoE double null mice develop severe
atherosclerosis within 4 weeks, whereas ApoE null mice take several months to develop the
disease, indicating that SR-BI plays a pivotal role in atherosclerosis. Importantly, SR-
BI/ApoE double null mice have lower plasma cholesterol levels than ApoE null mice,
suggesting involvement of a non-lipids mechanism. In the present study, we revealed a
novel ligand-independent apoptotic pathway induced by SR-BI, and regulated by …
atherosclerosis within 4 weeks, whereas ApoE null mice take several months to develop the
disease, indicating that SR-BI plays a pivotal role in atherosclerosis. Importantly, SR-
BI/ApoE double null mice have lower plasma cholesterol levels than ApoE null mice,
suggesting involvement of a non-lipids mechanism. In the present study, we revealed a
novel ligand-independent apoptotic pathway induced by SR-BI, and regulated by …