[HTML][HTML] Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function
D Xu, A Makkinje, JM Kyriakis - Journal of Biological Chemistry, 2005 - ASBMB
We report a mechanism by which the adapter protein Gene 33 (also called RALT and MIG6)
regulates epidermal growth factor receptor (EGFR) signaling. We find that Gene 33 inhibits
EGFR autophosphorylation and specifically blunts epidermal growth factor (EGF)-induced
activation and/or phosphorylation of Ras, ERK, JNK, Akt/PKB, and retinoblastoma protein.
The Ack homology domain of Gene 33, which contains the previously identified EGFR
binding domain, is both necessary and sufficient for this inhibition of EGFR …
regulates epidermal growth factor receptor (EGFR) signaling. We find that Gene 33 inhibits
EGFR autophosphorylation and specifically blunts epidermal growth factor (EGF)-induced
activation and/or phosphorylation of Ras, ERK, JNK, Akt/PKB, and retinoblastoma protein.
The Ack homology domain of Gene 33, which contains the previously identified EGFR
binding domain, is both necessary and sufficient for this inhibition of EGFR …
