Polycystin-1, the protein defective in a majority of patients with autosomal dominant
polycystic kidney disease, is a ubiquitously expressed multi-span transmembrane protein of
unknown function. Subcellular localization studies found this protein to be a component of
various cell junctional complexes and to be associated with the cytoskeleton, but the
specificity and nature of such associations are not known. To identify proteins that interact
with the polycystin-1 C-tail (P1CT), this segment was used as bait in a yeast two-hybrid …