Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels
Pore size is of considerable interest in voltage-gated Ca 2+ channels because they
exemplify a fundamental ability of certain ion channels: to display large pore diameter, but
also great selectivity for their ion of choice. We determined the pore size of several voltage-
dependent Ca 2+ channels of known molecular composition with large organic cations as
probes. T-type channels supported by the Ca V 3.1, Ca V 3.2, and Ca V 3.3 subunits; L-type
channels encoded by the Ca V 1.2, β 1, and α 2 δ 1 subunits; and R-type channels encoded …
exemplify a fundamental ability of certain ion channels: to display large pore diameter, but
also great selectivity for their ion of choice. We determined the pore size of several voltage-
dependent Ca 2+ channels of known molecular composition with large organic cations as
probes. T-type channels supported by the Ca V 3.1, Ca V 3.2, and Ca V 3.3 subunits; L-type
channels encoded by the Ca V 1.2, β 1, and α 2 δ 1 subunits; and R-type channels encoded …
