[HTML][HTML] Glucocorticoids induce proteasome C3 subunit expression in L6 muscle cells by opposing the suppression of its transcription by NF-κB
Muscle wasting in catabolic conditions results from activation of the ubiquitin-proteasome
proteolytic pathway by a process that requires glucocorticoids and is generally associated
with increased levels of mRNAs encoding components of this proteolytic system. In L6
muscle cells, dexamethasone stimulates proteolysis and increases the amount of the
proteasome C3 subunit protein by augmenting its transcription. Transfection studies with
human C3 promoter-luciferase reporter genes and electrophoretic mobility shift assays …
proteolytic pathway by a process that requires glucocorticoids and is generally associated
with increased levels of mRNAs encoding components of this proteolytic system. In L6
muscle cells, dexamethasone stimulates proteolysis and increases the amount of the
proteasome C3 subunit protein by augmenting its transcription. Transfection studies with
human C3 promoter-luciferase reporter genes and electrophoretic mobility shift assays …