[HTML][HTML] Characterization of interferon-α 13, a novel constitutive murine interferon-α subtype
V Van Pesch, T Michiels - Journal of Biological Chemistry, 2003 - ASBMB
Type-I interferons (IFNs), also called IFNs-α/β, are a family of cytokines induced by viral
infection and are primarily involved in antiviral defense of the cells. IFNs-α/β were also
reported to be produced constitutively at low levels in mouse and human cells. These so-
called endogenous or constitutive IFNs are thought to exert important homeostatic functions
in the uninfected host. By searching IFN genes that were not repressed by the leader protein
of Theiler's virus, we identified three uncharacterized IFN-α genes that are constitutively …
infection and are primarily involved in antiviral defense of the cells. IFNs-α/β were also
reported to be produced constitutively at low levels in mouse and human cells. These so-
called endogenous or constitutive IFNs are thought to exert important homeostatic functions
in the uninfected host. By searching IFN genes that were not repressed by the leader protein
of Theiler's virus, we identified three uncharacterized IFN-α genes that are constitutively …
