Interleukin-12 stimulates B cell growth by inducing IFN-γ
L Li, D Young, SF Wolf, YS Choi - Cellular immunology, 1996 - Elsevier
Human interleukin-12 (IL-12) is a 70-kDa polypeptide that activates human natural killer
cells. It has been purified from the culture supernatant of a human Epstein–Barr virus-
transformed B cell line and cloned. We show that native as well as recombinant IL-12
promoted growth ofStaphylococcus aureusCowan I strain (SAC) or anti-μ antibody-activated
B cells in a dose-dependent manner. IL-12 also acted in synergy with IL-2 in growth and
differentiation of SAC-activated B cells. Since anti-interferon (IFN)-γ antibody completely …
cells. It has been purified from the culture supernatant of a human Epstein–Barr virus-
transformed B cell line and cloned. We show that native as well as recombinant IL-12
promoted growth ofStaphylococcus aureusCowan I strain (SAC) or anti-μ antibody-activated
B cells in a dose-dependent manner. IL-12 also acted in synergy with IL-2 in growth and
differentiation of SAC-activated B cells. Since anti-interferon (IFN)-γ antibody completely …