[HTML][HTML] Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney
T Yin, G Sandhu, CD Wolfgang, A Burrier… - Journal of Biological …, 1997 - ASBMB
In this report we investigate the molecular mechanisms that contribute to tissue damage
following ischemia and ischemia coupled with reperfusion (ischemia/reperfusion) in the rat
heart and kidney. We observe the activation of three stress-inducible mitogen-activated
protein (MAP) kinases in these tissues: p38 MAP kinase and the 46-and 55-kDa isoforms of
Jun N-terminal kinase (JNK 46 and JNK 55). The heart and kidney show distinct time
courses in the activation of p38 MAP kinase during ischemia but no activation of either JNK …
following ischemia and ischemia coupled with reperfusion (ischemia/reperfusion) in the rat
heart and kidney. We observe the activation of three stress-inducible mitogen-activated
protein (MAP) kinases in these tissues: p38 MAP kinase and the 46-and 55-kDa isoforms of
Jun N-terminal kinase (JNK 46 and JNK 55). The heart and kidney show distinct time
courses in the activation of p38 MAP kinase during ischemia but no activation of either JNK …